HLA and cell-mediated immunity in HBsAg negative chronic active hepatitis.
نویسندگان
چکیده
In 20 patients with severe HBsAg negative chronic active hepatitis a significant association has been found between the HLA determinants A1, B8, and Dw3 and cell-mediated immunity directed against human liver specific lipoprotein in vitro. This observation induces further speculation that genetic immunoregulatory action might be involved in the pathogenetic mechanisms of chronic active hepatitis in vivo.
منابع مشابه
بررسی پلی مورفیسم آلل های HLA-DRB,DQA1,DQB1 در بیماران هپاتیت B مزمن در مقایسه با افراد سالم به روش PCR-SSP
Background: The outcome of acute hepatitis B infection may be influenced by host genetic factors like human leukocyte antigen (HLA). To investigate the association between the HLA-DRB, DQA1 and DQB1 alleles and chronic hepatitis B infection, 50 patients with chronic hepatitis B (based on 6 months positive of HBsAg and HBc antibody and HBeAg and antibody by serological test), were selected from ...
متن کاملT-lymphocyte cytotoxicity to HBsAg-coated target cells in hepatitis b virus infection.
The cytotoxic effect of peripheral lymphocytes on chicken red blood cells (ChRBC) coated with purified hepatitis B surface antigen (HBsAg) has been studied as an in vitro parameter of cell-mediated immunity in acute and chronic infection with hepatitis B virus. Using this technique, the mean cytotoxic index of lymphocytes from patients with acute hepatitis B (29.13 +/- 20.88) was significantly ...
متن کاملThe prevalence of HBsAg among pregnant women referred to Kerman maternity hospitals in 1997
Hepatitis B virus(HBV) is potentialy ba serious and lethal oathogen causing a wide range of diseases such as :fulminant hepatitis,cirrhisis,chronic active hepatitis,and hepatocellular carcinoma.moreover 5-10% of infected adults and 70-90% of infected neonates become chronic carriers,and these carriers are the source of spreading the infection among healthy individuals.the transmission of HBV fr...
متن کاملImpact of the Immunogen Nature on the Immune Response against the Major HBV Antigens in an HBsAg and HLA-humanized Transgenic Mouse Model
Hepatitis B chronic carriage remains as a major public health problem. Protein and DNA vaccines are now widely used in therapeutic vaccine candidates. Although, the hepatitis B surface antigen (HBsAg) based vaccines have been largely studied, candidates comprising both HBsAg and core (HBcAg) either protein- or DNA-based approaches deserve further immunological characterization. In the present s...
متن کاملHepatitis B Virus Lacks Immune Activating Capacity, but Actively Inhibits Plasmacytoid Dendritic Cell Function
Chronic hepatitis B virus (HBV) infection is caused by inadequate anti-viral immunity. Activation of plasmacytoid dendritic cells (pDC) leading to IFNα production is important for effective anti-viral immunity. Hepatitis B virus (HBV) infection lacks IFNα induction in animal models and patients and chronic HBV patients display impaired IFNα production by pDC. Therefore, HBV and HBV-derived prot...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Gut
دوره 20 6 شماره
صفحات -
تاریخ انتشار 1979